From 4bf7499672701e24c0bcd5ae3fb2b014ea82217d Mon Sep 17 00:00:00 2001 From: Charles Date: Mon, 15 Oct 2018 15:44:25 +0900 Subject: [PATCH] =?utf8?q?Caf=C3=A9?= MIME-Version: 1.0 Content-Type: text/plain; charset=utf8 Content-Transfer-Encoding: 8bit --- biblio/30293719.mdwn | 18 ++++++++++++++++++ 1 file changed, 18 insertions(+) create mode 100644 biblio/30293719.mdwn diff --git a/biblio/30293719.mdwn b/biblio/30293719.mdwn new file mode 100644 index 00000000..0038211a --- /dev/null +++ b/biblio/30293719.mdwn @@ -0,0 +1,18 @@ +[[!meta title="Prevalence of Mutation-Prone Microhomology-Mediated End Joining in a Chordate Lacking the c-NHEJ DNA Repair Pathway."]] +[[!tag Oikopleura mutation]] + +Deng W, Henriet S, Chourrout D. + +Curr Biol. 2018 Sep 27. pii: S0960-9822(18)31132-1. doi:10.1016/j.cub.2018.08.048 + +Prevalence of Mutation-Prone Microhomology-Mediated End Joining in a Chordate Lacking the c-NHEJ DNA Repair Pathway. + +[[!pmid 30293719 desc="In circularisation assays, the ratio between end-joining +and homologous recombination is similar in O. dioica compared with other +eukaryotes. Nevertheless, end-joining is more likely to concatenate than to +circularise linear plasmids. The presence of microhomologies trigger +microdeletions, consistend with the absence of the “classical” end-joining +pathway. These microdeletions are much more frequent than in other organisms. +Comparisons between Norvegian and Japanese strains suggest that the +microdeletions could be part of the mechansism driving the compaction of O. +dioica's genome."]] -- 2.47.3