From 1e85514a55b70adcb66f0294c827295b1aa87079 Mon Sep 17 00:00:00 2001 From: Charles Date: Thu, 25 Jun 2020 12:50:13 +0900 Subject: [PATCH] =?utf8?q?Caf=C3=A9?= MIME-Version: 1.0 Content-Type: text/plain; charset=utf8 Content-Transfer-Encoding: 8bit --- biblio/32513727.mdwn | 10 ++++++++++ tags/mitochondrion.mdwn | 3 +++ 2 files changed, 13 insertions(+) create mode 100644 biblio/32513727.mdwn diff --git a/biblio/32513727.mdwn b/biblio/32513727.mdwn new file mode 100644 index 00000000..f40cba48 --- /dev/null +++ b/biblio/32513727.mdwn @@ -0,0 +1,10 @@ +[[!meta title="Elimination of rNMPs from mitochondrial DNA has no effect on its stability."]] +[[!tag mitochondrion]] + +Elimination of rNMPs from mitochondrial DNA has no effect on its stability. + +Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14306-14313 + +Wanrooij PH, Tran P, Thompson LJ, Carvalho G, Sharma S, Kreisel K, Navarrete C, Feldberg AL, Watt DL, Nilsson AK, Engqvist MKM, Clausen AR, Chabes A. + +[[!pmid 32513727 desc="In mouse, mitochondrial DNA strands have a few (usually ~10 or less) ribonucleotides misincorporated into them. Their number correlate with the ration between rNTPs and dNTPs. Reducing misincorporation did not have obvious benefits for the animals. "]] diff --git a/tags/mitochondrion.mdwn b/tags/mitochondrion.mdwn index 355dde86..318a642c 100644 --- a/tags/mitochondrion.mdwn +++ b/tags/mitochondrion.mdwn @@ -87,4 +87,7 @@ Mitochondria can be lost in eukaryotes, be them monocellular ([[Karnkowska and coll., 2019|biblio/31387118]]), or multicellular ([[Yahalomi and coll., 2020|biblio/32094163]]). +Mitochondrial DNA has a few rNTP misincorporated, but they do not seem to be +detrimental ([[Wanrooij and coll., 2020|biblio/32513727]]). + [[!inline pages="tagged(mitochondrion)" limit=0]] -- 2.47.3