From 1c44108bdee14df00d103cd176fd4d95fe068636 Mon Sep 17 00:00:00 2001 From: Charles Date: Fri, 11 Jun 2021 12:59:59 +0900 Subject: [PATCH] =?utf8?q?Caf=C3=A9?= MIME-Version: 1.0 Content-Type: text/plain; charset=utf8 Content-Transfer-Encoding: 8bit --- biblio/34107272.mdwn | 10 ++++++++++ tags/Oikopleura.mdwn | 2 ++ 2 files changed, 12 insertions(+) create mode 100644 biblio/34107272.mdwn diff --git a/biblio/34107272.mdwn b/biblio/34107272.mdwn new file mode 100644 index 00000000..f5ea2a1e --- /dev/null +++ b/biblio/34107272.mdwn @@ -0,0 +1,10 @@ +[[!meta title="Nkx2-1 and FoxE regionalize glandular (mucus-producing) and thyroid-equivalent traits in the endostyle of the chordate Oikopleura dioica."]] +[[!tag Oikopleura]] + +Onuma TA, Nakanishi R, Sasakura Y, Ogasawara M. + +Dev Biol. 2021 Jun 6:S0012-1606(21)00142-1. doi: 10.1016/j.ydbio.2021.05.021. + +Nkx2-1 and FoxE regionalize glandular (mucus-producing) and thyroid-equivalent traits in the endostyle of the chordate Oikopleura dioica. + +[[!pmid 34107272 desc="Found vWFL (von Willebrand factor-like, a single gene, whereas Ciona has two), and the thyroid-related peroxidases, TPO and Duox, and the thyroid-related TFs Nkx2-1 and FoxE. Also reported a SCO spondin in the supplemental material. “Nkx2-1 knockdown suppressed vWFL expression in 8 hpf larvae. In contrast, FoxE knockdown had no effect on vWFL expression.” “Nkx2-1 knockdown decreased TPO expression in the endostyle of over 90% of larvae.” “FoxE knockdown did not affect Duox expression.” “Nkx2-1 knockdown caused malformation of the endostyle in 80% of the larvae. In contrast, FoxE knockdown did not affect endostyle morphology.” “Nkx2-1 expression was decreased by Nkx2-1 knockdown, but not by FoxE knockdown. On the other hand, FoxE expression was decreased in two-thirds of the Nkx2-1 knockdown larvae as well as in FoxE knockdown larvae.”"]] diff --git a/tags/Oikopleura.mdwn b/tags/Oikopleura.mdwn index c62f3ace..86c71c2c 100644 --- a/tags/Oikopleura.mdwn +++ b/tags/Oikopleura.mdwn @@ -236,6 +236,8 @@ Genes and pathways - Metallothioneins _OdMT1_ and _OdMT2_ [[Calatayud and coll., 2018|biblio/30284576]]. - 2 NUMB genes were found; both are closer to Vertebrate NUMB than to Vertebrate NUMB-Like ([[Confalonieri and coll., 2019|biblio/31451549]]). + - Genes related to thyroid functions (_vWFL_, _Nkx2-1_, _FoxE_, _TPO_ and _Duox_) + were studied by [[Onuma and coll., 2020|biblio/34107272]]. ### Lost -- 2.47.3