From 0847223f5a5a872c1a90afb3ac1ca293425cbe7b Mon Sep 17 00:00:00 2001 From: Charles Plessy Date: Mon, 8 May 2023 09:17:00 +0900 Subject: [PATCH] APEX2 / APE2 --- tags/Oikopleura.mdwn | 2 ++ 1 file changed, 2 insertions(+) diff --git a/tags/Oikopleura.mdwn b/tags/Oikopleura.mdwn index 475eb22c..3791499b 100644 --- a/tags/Oikopleura.mdwn +++ b/tags/Oikopleura.mdwn @@ -276,6 +276,8 @@ Genes and pathways ([[Niimura, 2009|biblio/20333175]]). - Most members of retinoic acid pathway gene network (biosynthesis, signalling and degradation) are lost in _O. dioica_ ([[Martí-Solans et al., 2016|biblio/27406791]]). + - APEX2 (encoding for the APE2 protein involved in base excision repair and microhomology + mediated end-joining (MMEJ) was not found, but APEX1 was found ([[Denoeud et al., 2010|biblio/21097902]]). - The entire machinery required for performing classical NHEJ repair of DSB (which is conserved from yeast to mammals) is undetectable ([[Denoeud et al., 2010|biblio/21097902]]). An alternative or microhomology (MH)-driven end joining pathway is active -- 2.47.3