From: Charles Date: Thu, 7 Jan 2021 04:20:00 +0000 (+0900) Subject: Café X-Git-Url: https://source.charles.plessy.org/?a=commitdiff_plain;h=c5a5e0889ed46558f72cb812da670cf9102a7107;p=source%2F.git Café --- diff --git a/biblio/31451549.mdwn b/biblio/31451549.mdwn new file mode 100644 index 00000000..8b60d2d9 --- /dev/null +++ b/biblio/31451549.mdwn @@ -0,0 +1,10 @@ +[[!meta title="Exon 3 of the NUMB Gene Emerged in the Chordate Lineage Coopting the NUMB Protein to the Regulation of MDM2."]] +[[!tag Ciona Oikopleura]] + +Exon 3 of the NUMB Gene Emerged in the Chordate Lineage Coopting the NUMB Protein to the Regulation of MDM2. + +Confalonieri S, Colaluca IN, Basile A, Pece S, Di Fiore PP. + +G3 (Bethesda). 2019 Oct 7;9(10):3359-3367. doi: 10.1534/g3.119.400494. + +[[!pmid 31451549 desc="Ciona NUMB can inhibit ubiquitination of P53 by MDM2. This and a phylogenetic analysis demonstrates that PTB-long isoform encoded by Exon3 is a Chordate invention. O. dioica has 2 NUMB genes, more similar to NUMB than to vertebrate-specific NUMBL. Their intron/exon structures are different from any other organism."]] diff --git a/tags/Oikopleura.mdwn b/tags/Oikopleura.mdwn index 7821f2c2..7a6f9891 100644 --- a/tags/Oikopleura.mdwn +++ b/tags/Oikopleura.mdwn @@ -227,6 +227,8 @@ Genes and pathways Tolstenkov and Glover 2019|biblio/30905687]]). - Piwi ([[Henriet and coll., 2015|biblio/25779047]]). - Metallothioneins _OdMT1_ and _OdMT2_ [[Calatayud and coll., 2018|biblio/30284576]]. + - 2 NUMB genes were found; both are closer to Vertebrate NUMB than to Vertebrate NUMB-Like + ([[Confalonieri and coll., 2019|biblio/31451549]]). ### Lost