From: Charles Plessy Date: Wed, 26 Jul 2017 02:20:11 +0000 (+0900) Subject: Biblio. X-Git-Url: https://source.charles.plessy.org/?a=commitdiff_plain;h=7257af271993b1ac1b52bd35720dbce445130909;p=source%2F.git Biblio. --- diff --git a/biblio/28673998.mdwn b/biblio/28673998.mdwn new file mode 100644 index 00000000..f2ca67de --- /dev/null +++ b/biblio/28673998.mdwn @@ -0,0 +1,10 @@ +[[!meta title="Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex."]] +[[!tag cap]] + +Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):7659-7664. doi:10.1073/pnas.1704006114 + +Zhang W, Tam CP, Walton T, Fahrenbach AC, Birrane G, Szostak JW. + +Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex. + +[[!pmid desc="« The formation of two Watson–Crick base pairs leads to a much higher affinity of GpppG than GMP for a CC template (Kd of ∼0.2 mM vs. ∼20 mM, respectively). » « The tight binding of GpppG to a CC template suggests that GpppG might be an ideal primer for the initiation of template copying by primer extension. The resulting RNAs would begin with a 5ʹ cap-like GpppG moiety, suggesting a potential evolutionary origin for the eukaryotic mRNA 5ʹ-cap structure. »"]]