From: Charles Date: Mon, 15 Oct 2018 06:44:25 +0000 (+0900) Subject: Café X-Git-Url: https://source.charles.plessy.org/?a=commitdiff_plain;h=4bf7499672701e24c0bcd5ae3fb2b014ea82217d;p=source.git Café --- diff --git a/biblio/30293719.mdwn b/biblio/30293719.mdwn new file mode 100644 index 00000000..0038211a --- /dev/null +++ b/biblio/30293719.mdwn @@ -0,0 +1,18 @@ +[[!meta title="Prevalence of Mutation-Prone Microhomology-Mediated End Joining in a Chordate Lacking the c-NHEJ DNA Repair Pathway."]] +[[!tag Oikopleura mutation]] + +Deng W, Henriet S, Chourrout D. + +Curr Biol. 2018 Sep 27. pii: S0960-9822(18)31132-1. doi:10.1016/j.cub.2018.08.048 + +Prevalence of Mutation-Prone Microhomology-Mediated End Joining in a Chordate Lacking the c-NHEJ DNA Repair Pathway. + +[[!pmid 30293719 desc="In circularisation assays, the ratio between end-joining +and homologous recombination is similar in O. dioica compared with other +eukaryotes. Nevertheless, end-joining is more likely to concatenate than to +circularise linear plasmids. The presence of microhomologies trigger +microdeletions, consistend with the absence of the “classical” end-joining +pathway. These microdeletions are much more frequent than in other organisms. +Comparisons between Norvegian and Japanese strains suggest that the +microdeletions could be part of the mechansism driving the compaction of O. +dioica's genome."]]