From: Charles Date: Tue, 14 Jan 2020 06:11:38 +0000 (+0900) Subject: Café X-Git-Url: https://source.charles.plessy.org/?a=commitdiff_plain;h=302fab1cd66c0ede70193cfb51bd78e76db941bc;p=source%2F.git Café --- diff --git a/biblio/26586757.mdwn b/biblio/26586757.mdwn new file mode 100644 index 00000000..6c988fd3 --- /dev/null +++ b/biblio/26586757.mdwn @@ -0,0 +1,10 @@ +[[!meta title="Stable recombination hotspots in birds."]] +[[!tag H3K4me3 meiosis]] + +Singhal S, Leffler EM, Sannareddy K, Turner I, Venn O, Hooper DM, Strand AI, Li Q, Raney B, Balakrishnan CN, Griffith SC, McVean G, Przeworski M. + +Science. 2015 Nov 20;350(6263):928-32. doi:10.1126/science.aad0843 + +Stable recombination hotspots in birds. + +[[!pmid 26586757 desc="Recombination maps obtained from genome sequences of 24 zebra finches and 20 long-tail finches, in which SNP Haplotypes were inferred from phase-informative reads and family phasing. Recombination rates estimated as ρ = 26.2/kb and 14.0/kb, respectively (0.14 cM/Mb in both species). 3—4000 Hotspots “operationally defined them as regions that are at least 2 kb in length; have at least five times the background recombination rate as estimated across the 80 kb of sequence surrounding the region; and are statistically supported as hotspots by a likelihood ratio test” (18). “73% of zebra finch hotspots (...) were detected as shared between the two species.” “Hotspots in the zebra finch and long-tailed finch genomes are enriched near transcription start sites (TSSs), transcription stop sites (TESs), and CpG islands (CGIs), with close to half of all hotspots occurring within 3 kb of one of these features.” “Median recombination rates across and within chromosomes vary over nearly six orders of magnitude (...) with regions of elevated recombination near telomeres and large intervening deserts."]]