From: Charles Plessy Date: Wed, 8 Feb 2023 05:23:56 +0000 (+0900) Subject: Details on mechanism. X-Git-Url: https://source.charles.plessy.org/?a=commitdiff_plain;h=2015bfb0f40274fb6f86b571c2aa4f0fd3aa3672;p=source%2F.git Details on mechanism. --- diff --git a/tags/variants.mdwn b/tags/variants.mdwn index 65fbf91b..222faccd 100644 --- a/tags/variants.mdwn +++ b/tags/variants.mdwn @@ -51,6 +51,9 @@ Flanking an inversion in _D. buzzati_ between two _Galileo_ elements, the exchange of Target-Site Duplication sequences was observed by Cáceres and coll., [[(1999|biblio/10411506]]). +Ectopic recombination of a Galileo element may have caused a recent large-scale +inversion in _D. buzzati_ ([[Delprat and coll, 2009|biblio/19936241]]). + [[Kent and coll., 2003|biblio/14500911]] reported 2 inversions per Mbp in human/mouse comparisons, median length 814. @@ -60,8 +63,11 @@ _Staggered breaks_ ([[Ranz and coll., 2007|bilbio/17550304]]) caused by inverted duplications. The duplicated sequnces may be coding genes or pseudogenes, not just transposable elements. -Ectopic recombination of a Galileo element may have caused a recent large-scale -inversion in _D. buzzati_ ([[Delprat and coll, 2009|biblio/19936241]]). +([[Delprat and coll, 2009|biblio/19936241]]) proposed that “Chromosomal +inversions may be generated by transposons when two ends that are not part of +the same transposon participate in an aberrant transposition event to a new +site”. They give an example where the two transposons are identical copies +on sister chromatids in G2 phase. ## Software