From: Charles Date: Thu, 25 Jun 2020 03:50:13 +0000 (+0900) Subject: Café X-Git-Url: https://source.charles.plessy.org/?a=commitdiff_plain;h=1e85514a55b70adcb66f0294c827295b1aa87079;p=source.git Café --- diff --git a/biblio/32513727.mdwn b/biblio/32513727.mdwn new file mode 100644 index 00000000..f40cba48 --- /dev/null +++ b/biblio/32513727.mdwn @@ -0,0 +1,10 @@ +[[!meta title="Elimination of rNMPs from mitochondrial DNA has no effect on its stability."]] +[[!tag mitochondrion]] + +Elimination of rNMPs from mitochondrial DNA has no effect on its stability. + +Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14306-14313 + +Wanrooij PH, Tran P, Thompson LJ, Carvalho G, Sharma S, Kreisel K, Navarrete C, Feldberg AL, Watt DL, Nilsson AK, Engqvist MKM, Clausen AR, Chabes A. + +[[!pmid 32513727 desc="In mouse, mitochondrial DNA strands have a few (usually ~10 or less) ribonucleotides misincorporated into them. Their number correlate with the ration between rNTPs and dNTPs. Reducing misincorporation did not have obvious benefits for the animals. "]] diff --git a/tags/mitochondrion.mdwn b/tags/mitochondrion.mdwn index 355dde86..318a642c 100644 --- a/tags/mitochondrion.mdwn +++ b/tags/mitochondrion.mdwn @@ -87,4 +87,7 @@ Mitochondria can be lost in eukaryotes, be them monocellular ([[Karnkowska and coll., 2019|biblio/31387118]]), or multicellular ([[Yahalomi and coll., 2020|biblio/32094163]]). +Mitochondrial DNA has a few rNTP misincorporated, but they do not seem to be +detrimental ([[Wanrooij and coll., 2020|biblio/32513727]]). + [[!inline pages="tagged(mitochondrion)" limit=0]]