From: Charles Plessy Date: Mon, 6 Dec 2021 10:23:05 +0000 (+0900) Subject: ahem X-Git-Url: https://source.charles.plessy.org/?a=commitdiff_plain;h=14debffe10746bc0cc4ff03b30b78f4cb6756364;p=source.git ahem --- diff --git a/biblio/22751100.mdwn b/biblio/22751100.mdwn new file mode 100644 index 00000000..d0af8f66 --- /dev/null +++ b/biblio/22751100.mdwn @@ -0,0 +1,10 @@ +[[!meta title="Structural diversity and African origin of the 17q21.31 inversion polymorphism."]] +[[!tag variants]] + +Steinberg KM, Antonacci F, Sudmant PH, Kidd JM, Campbell CD, Vives L, Malig M, Scheinfeldt L, Beggs W, Ibrahim M, Lema G, Nyambo TB, Omar SA, Bodo JM, Froment A, Donnelly MP, Kidd KK, Tishkoff SA, Eichler EE. + +Nat Genet. 2012 Jul 1;44(8):872-80. doi:10.1038/ng.2335 + +Structural diversity and African origin of the 17q21.31 inversion polymorphism. + +[[!pmid 22751100 desc="“In conclusion, we propose that the ancestral H2′ haplotype arose in eastern or central Africa and spread to southern Africa before the emergence of anatomically modern humans (Fig. 6). Approximately 2.3 million years ago, the inversion rearranged to what we now refer as the direct orientation haplotype (H1′).”"]] diff --git a/tags/variants.mdwn b/tags/variants.mdwn index 98eb189d..9bc58e57 100644 --- a/tags/variants.mdwn +++ b/tags/variants.mdwn @@ -32,7 +32,8 @@ suppress crossovers not only inside the inversion but also close to it (within 1 genome and calculated that it appeared ~3 million years ago, before the speciation of _Homo sapiens_. Low-copy repeated sequences were found in the vicinity. [[Donelly and coll., 2010|biblio/20116045]] gave a radically lower -time estimate of 13,600 to 108,400 years. +time estimate of 13,600 to 108,400 years, but an ancient origin was again +supported by [[Steinberg and coll in 2012|biblio/22751100]]. ### Software