From: Charles Plessy <charles.plessy@oist.jp>
Date: Thu, 11 Nov 2021 04:30:44 +0000 (+0900)
Subject: Café
X-Git-Url: https://source.charles.plessy.org/?a=commitdiff_plain;h=087da52f239b10bd3464d29dad4f5a443a980d82;p=source%2F.git

Café
---

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+[[!meta title="DNA repair inhibition leads to active export of repetitive sequences to the cytoplasm triggering an inflammatory response."]]
+[[!tag repeat repair brain]]
+
+Song X, Aw JTM, Ma F, Cheung MF, Leung D, Herrup K.
+
+J Neurosci. 2021 Sep 28:JN-RM-0845-21. doi:10.1523/JNEUROSCI.0845-21.2021.
+
+DNA repair inhibition leads to active export of repetitive sequences to the cytoplasm triggering an inflammatory response. 
+
+[[!pmid 34593604 desc="Microglial cells accumulate cytoplasmic DNA by damage or inhibition of repair.  Blocking DNA export reduces accumulation of cytoplasmic DNA and inflamation.  Transcriptionally inactive sequences, AT-rich regions and repeated elements are enriched in the cytoplasmic DNA fraction."]]