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+[[!meta title="Inversions in the Chromosomes of Drosophila Pseudoobscura."]]
+[[!tag Drosophila variants]]
+
+Dobzhansky T, Sturtevant AH
+
+Genetics. 1938 Jan;23(1):28-64. doi:10.1093/genetics/23.1.28
+
+Inversions in the Chromosomes of Drosophila Pseudoobscura.
+
+[[!pmid 17246876 desc="Observation of polytene chromosomes in salivary glands of hybrid _D. pseudoobscura_ crossed form different populations showed lage-scale inversions in the 3rd chromosome.  The collection of haplotypes can be represented as a graph linking single inversion events.  Multiple haplotypes may coexist in the same geographical region."]]

diff --git a/tags/Drosophila.mdwn b/tags/Drosophila.mdwn
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--- a/tags/Drosophila.mdwn
+++ b/tags/Drosophila.mdwn
@@ -12,6 +12,12 @@ and Nei  (1995)|biblio/7739381]]) suggests that D. mel and D. pseudoobscura
 diverged 24.9 +/- 2.88 My ago, based on the assumption that D. picticornis and
 D. silvestris diverged 5.1 My ago.
 
+Variations of the gene order in the chromosome 3 of _D. Pseudoobscura_ were
+reported by [[Dobzhansky and Sturtevant|biblio/17246876]] in 1938, who could
+describe them as a network of successive large-scale inversions.  They also
+showed that the gene order of the X2 chromosome of _D. miranda_ is homologoues
+to the one of the hypothetical ancestor of chromosome 3 in _D. Pseudoobscura_.
+
 The ITS2 sequence of Drosophila species diverged at the speed of 1.2 % per million
 year ([[Schlötterer and coll., 1994|biblio/8015444]]).
 

diff --git a/tags/variants.mdwn b/tags/variants.mdwn
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+++ b/tags/variants.mdwn
@@ -15,11 +15,16 @@ selection and increased genetic load in inversions and other types of variants
 [[Hämälä and coll., 2021|biblio/34408075]].
 
 ~1100 small-scale inversions are estimated to have happened between _S.
-cerevisiae_ and _C. albicans_ ([[|biblio/11087826]]).  The authors propose that
+cerevisiae_ and _C. albicans_ ([[Seoighe and coll., 2000|biblio/11087826]]).  The authors propose that
 “successive multigene inversions” have “distrupted” the “precise arrangement”
 of “genes that are adjacent in one species are in the same neighborhood”.  A
 “bias toward small inversions” is reported.
 
+A collection of gene arrangements where each pair is related is related by a
+single large-scale inversion was found by [[Dobzhansky and
+Sturtevant|biblio/17246876]] in _D. pseudoobscura_.
+
+
 ### Software
 
  - _NanoSV_ ([[Cretu Stancu and coll., 2017|biblio/29109544]]) uses nanopore long