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+[[!meta title="Switching of INCENP paralogs controls transitions in mitotic chromosomal passenger complex functions."]]
+[[!tag Oikopleura centromere H3T3p H3S28p H3S10p H3S31p H3K4me2 H3K9me3]]
+
+Cell Cycle. 2019 Jul 15:1-20. doi:10.1080/15384101.2019.1634954
+
+Feng H, Raasholm M, Moosmann A, Campsteijn C, Thompson EM.
+
+Switching of INCENP paralogs controls transitions in mitotic chromosomal passenger complex functions.
+
+[[!pmid 31306061 desc="Components of the constitutive centromere-associated network (CCAN) at the inner kinetochore seem to be missing in the genome. H3T3p and H3S28p mark inner centromeric regions (single spots) and H3T11p mark outer centromeric regions (pairs of spots). Fluorescent microscopy pictures supporting a 2 × 3 karyotype."]]
There are also intriguing observations of somatic mitotic cells with 7
chromosomes ([[Körner, 1952|biblio/43261846]]) and meiotic cells with
8 haploid chromosomes ([[Colombera & Fenaux, 1973|biblio/10.1080_11250007309429248]]).
+ - Several manuscripts using animals from the SARS laboratory include
+ fluorescent microscopy pictures supporting the 3 × 2 karyotype. For instance:
+ centromere marking in [[Feng and coll., 2019|biblio/31306061]].
- Each cell only contains 70 fg of DNA ([Animal Genome Size Database](http://www.genomesize.com/result_species.php?id=1308)).
- Genome size estimated to 72 ± 13 Mb (min 32.6~65 Mb) by [[Seo et al,
2001|biblio/11752568]]. A 70.4 Mb genome "reference assembly" was later
retrotransposition.
- Duplications in the Rab family: Rab5/17, Rab6, Rab7, Rab10, Rab35. The EF-Rab chimera
Rab46 is kept ([[Coppola and coll., 2019|biblio/31028425]]). See below for the losses.
+ - INCENP and Plk1 are duplicated ([[Feng and coll., 2019|biblio/31306061]]).
### Lost
- More than 50 % of the Rab family is lost ([[Coppola and coll., 2019|biblio/31028425]]):
Rab4, Rab7L1, Rab9, Rab19/43, Rab21 Rab26/37, Rab28, Ift27, RabX1 and the
the EF-rab chimera Rasef and EFcab4/Rab44.
-
+ - Components of the constitutive centromere-associated network (CCAN) of the
+ inner kinetochore cound not be found in the genome by ([[Feng and coll.,
+ 2019|biblio/31306061]]).
Epigenome
---------