Onigiri

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+[[!meta title="Synthetic transcription elongation factors license transcription across repressive chromatin."]]
+[[!tag drug elongation polyamides]]
+
+Erwin GS, Grieshop MP, Ali A, Qi J, Lawlor M, Kumar D, Ahmad I, McNally A,
+Teider N, Worringer K, Sivasankaran R, Syed DN, Eguchi A, Ashraf M, Jeffery J, Xu
+M, Park PMC, Mukhtar H, Srivastava AK, Faruq M, Bradner JE, Ansari AZ.
+
+Science. 2017 Nov 30. pii: eaan6414. doi:10.1126/science.aan6414
+
+Synthetic transcription elongation factors license transcription across repressive chromatin.
+
+[[!pmid 29192133 desc="Syn-TEFs.  A BET inhibitor drug (JQ1) linked to a pyrrole- and imidazole-based polyamide targetting the motif AAGAAGAAG rescues Frataxin (FXN) in patient cells by promoting transcript elongation to paused polymerases."]]