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+[[!meta title="Evolution of multiple CDK1 paralogs towards specializations in late cell cycle events in a lineage with fast developing planktonic embryos."]]
+[[!tag Oikopleura bioRxiv]]
+
+bioRxiv 817783; doi: https://doi.org/10.1101/817783
+
+Xiaofei Ma. Jan Inge Øvrebø, Eric M Thompson.
+
+Evolution of multiple CDK1 paralogs towards specializations in late cell cycle events in a lineage with fast developing planktonic embryos.
+
+[[!doi 10.1101/817783 desc="“Interspecies clustering of CDK1 paralogs [show] conservation of their intron-exon structures” “_O. dioica_ CDK1a and b locate on the same autosome whereas CDK1c is present on a different autosome that also contains CDK1e. CDK1d is found on the X chromosome where, at a distance of 5 MB, the CycBa locus is also located.” “The PSTAIRE helix is modified in all Oikopleura CDK1 paralogs whereas Oikopleura CDK2s retain the canonical PSTAIRE sequence. All of the 17 identified Oikopleura CDK1 sequences share the A48S substitution.”"]]
intestinalis_ ([[Matthysse and coll., 2004|biblio/14722352]]).
- _O. dioica_ has multiple CDK1 and Cyclin B paraplogs, some of which are
implicated in oogenesis ([[Feng & Thompson, 2018|biblio/29969934]]).
+ - _O. dioica_ CDK1a and b locate on LG2; CDK1c and is CDK1e on LG1.
+ CDK1d is on the X chromosome near CycBa. In _O. albicans_, CDK1a,b and c are
+ on the same chromosome ([[Ma, Øvrebø and Thompson, 2019|biblio/10.1101_817783]]).
- _O. dioica_, like other deuterostomes, has acid-sensing ion channels (ASICs).
They are expressed in the nervous system ([[Lynagh et al., 2018|biblio/30061402]]).
- Some muscle genes were duplicated in the _Oikopleura_ stem lineage
[[Wang and coll., 2015|biblio/26032664]]).
- A `TCTAGA` promoter element is found in 73.5% of the non-trans-spliced genes detected with
CAGE in testis ([[Danks et al, 2018|biblio/29482522]]).
+ - “Maternal promoters in O. dioica were located on the X-chromosome more
+ frequently than expected” ([[Danks et al, 2018|biblio/29482522]]).
- Introns are very small (peak at 47 base pairs, 2.4% > 1 kb, [[Denoeud et
al., 2010|biblio/21097902]]) and subjected to a large turnover: many ancestral
introns are lost, and many new species-specific introns found ([[Edvarsen et