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+[[!meta title="Exon 3 of the NUMB Gene Emerged in the Chordate Lineage Coopting the NUMB Protein to the Regulation of MDM2."]]
+[[!tag Ciona Oikopleura]]
+
+Exon 3 of the NUMB Gene Emerged in the Chordate Lineage Coopting the NUMB Protein to the Regulation of MDM2.
+
+Confalonieri S, Colaluca IN, Basile A, Pece S, Di Fiore PP.
+
+G3 (Bethesda). 2019 Oct 7;9(10):3359-3367. doi: 10.1534/g3.119.400494.
+
+[[!pmid 31451549 desc="Ciona NUMB can inhibit ubiquitination of P53 by MDM2.  This and a phylogenetic analysis demonstrates that PTB-long isoform encoded by Exon3 is a Chordate invention. O. dioica has 2 NUMB genes, more similar to NUMB than to vertebrate-specific NUMBL.  Their intron/exon structures are different from any other organism."]]

diff --git a/tags/Oikopleura.mdwn b/tags/Oikopleura.mdwn
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--- a/tags/Oikopleura.mdwn
+++ b/tags/Oikopleura.mdwn
@@ -227,6 +227,8 @@ Genes and pathways
    Tolstenkov and Glover 2019|biblio/30905687]]).
  - Piwi ([[Henriet and coll., 2015|biblio/25779047]]).
  - Metallothioneins _OdMT1_ and _OdMT2_ [[Calatayud and coll., 2018|biblio/30284576]].
+ - 2 NUMB genes were found; both are closer to Vertebrate NUMB than to Vertebrate NUMB-Like
+   ([[Confalonieri and coll., 2019|biblio/31451549]]).
 
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