--- /dev/null
+[[!meta title="Evaluating genome dynamics: the constraints on rearrangements within bacterial genomes."]]
+[[!tag bacteria variants review]]
+
+Hughes D.
+
+Genome Biol. 2000;1(6):REVIEWS0006. doi: 10.1186/gb-2000-1-6-reviews0006.
+
+Evaluating genome dynamics: the constraints on rearrangements within bacterial genomes.
+
+[[!pmid 11380986 desc="Review reporting that “almost all rearrangements conserve the axis of chromosome replication”."]]
Collins (2000)|biblio/11017076]]. Both reports suggest that the patterns are
generated by inversions centered on origins and termini. The prevalence of
this phenomenon was confirmed by [[D'Iorio and Dewar, 2022|biblio/36261227]].
+The state of the art in bacterial genomics in 2000 was reviewed by
+[[Hughes|biblio/11380986]].
### Mechanism