heart

diff --git a/biblio/34789899.mdwn b/biblio/34789899.mdwn
new file mode 100644 (file)
index 0000000..8200ef1
--- /dev/null
+++ b/biblio/34789899.mdwn
@@ -0,0 +1,10 @@
+[[!meta title="Cardiopharyngeal deconstruction and ancestral tunicate sessility."]]
+[[!tag Oikopleura]]
+
+Ferrández-Roldán A, Fabregà-Torrus M, Sánchez-Serna G, Duran-Bello E, Joaquín-Lluís M, Bujosa P, Plana-Carmona M, Garcia-Fernàndez J, Albalat R, Cañestro C.
+
+Nature. 2021 Nov;599(7885):431-435. doi:10.1038/s41586-021-04041-w
+
+Cardiopharyngeal deconstruction and ancestral tunicate sessility.
+
+[[!pmid 34789899 desc="Mesp, Ets1/2b, Gata4/5/6, Mek1/2, Hand-r and Tbx1/10 are absent from appendicularian genomes.   Nk4, Hand1/2 and FoxF were found."]]

diff --git a/tags/Oikopleura.mdwn b/tags/Oikopleura.mdwn
index c5a596664f12eaa3268745dbaf8f33c8531b0597..e4e9fcb02441adc1b8bfdd8616c20d59c155b58c 100644 (file)
--- a/tags/Oikopleura.mdwn
+++ b/tags/Oikopleura.mdwn
@@ -252,6 +252,7 @@ Genes and pathways
  - 8 Wnt genes were found, belonging to 4 families.  Intronless _Wnt11_ genes
    were found; they might have been created by retrotransposition
    ([[Martí-Solans and coll., 2021|biblio/34179025]]).
+ - _Nk4_, _Hand1/2_ and _FoxF_ (heart development, [[Ferrández-Roldán and coll., 2021|biblio/34789899]]).
 
 ### Lost
 
@@ -285,7 +286,8 @@ Genes and pathways
  - _Nodal_ is not found in _O. dioica_'s genome ([[Onuma and coll., 2020|biblio/32029598]]).
  - Peroxysomes and genes related to them ([[Žárský and Tachezy, 2015|biblio/26700421]];
    [[Kienle, Kloepper and Fasshauer, 2016|biblio/27756227]]).
-
+ - _Mesp_, _Ets1/2b_, _Gata4/5/6_, _Mek1/2_,  _Hand-r_ and _Tbx1/10_ (heart development,
+   [[Ferrández-Roldán and coll., 2021|biblio/34789899]]).
 
 Epigenome
 ---------
@@ -457,7 +459,9 @@ Anatomy
    Electron microscopy shows a large perikaryon, cisternas and a cilium which is inserted
    in the central canal ([[Holmberg and Olsson, 1984|biblio/reissner_oik]]).
  - In contrary to Kowalevskiidae, ([[Brena, Cima and Burighel, 2003|biblio/10.1002_jmor.10145]]),
-   _Oikopleura_ do have a heart.
+   _Oikopleura_ do have a heart.  The genes _Mesp_, _Ets1/2b_, _Gata4/5/6_, _Mek1/2_,
+   _Hand-r_ and _Tbx1/10_, which are essential to heart development in other chordates
+   are lost in appendicularians ([[Ferrández-Roldán and coll., 2021|biblio/34789899]]).
  - A 3D reconstitution of hatchlings and jufeniles was done by SEM tomography by
    [[Nishida and coll., 2021|biblio/33649401]].