Café

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+[[!meta title="Prevalence of small inversions in yeast gene order evolution"]]
+[[!tag variants yeast]]
+
+Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14433-7. doi:10.1073/pnas.240462997
+
+Seoighe C, Federspiel N, Jones T, Hansen N, Bivolarovic V, Surzycki R, Tamse R, Komp C, Huizar L, Davis RW, Scherer S, Tait E, Shaw DJ, Harris D, Murphy L, Oliver K, Taylor K, Rajandream MA, Barrell BG, Wolfe KH.
+
+Prevalence of small inversions in yeast gene order evolution
+
+[[!pmid 11087826 desc="Classifies pairs of gene orientations as ”parallel”, “convergent”, “divergent” and “alternative parallel” and studies combinations of these orientations in 298 adjacent gene paris from the _S. cerevisiae_ and the _C. albicans_ genomes, and the number of inversions they imply.  “We estimate that about 1,100 single-gene inversions have occurred since the divergence between these species”  (divergence happened ~200 million years ago)  “Our results suggest that successive random small inversions frequently cause a gene's chromosomal position and orientation to drift during its evolution. This process would alter gene order and orientation without moving any genes very far from their starting points.”"]]

diff --git a/tags/variants.mdwn b/tags/variants.mdwn
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@@ -5,6 +5,8 @@ _in progress_
 Long read sequencing data from 3,622 Icelanders identified a median of 22,636
 SVs per individual (insertios: 13,353; deletions: 9,474) [[Beyter and coll, 2021|biblio/33972781]].
 
+### Inversions
+
 SNP analysis in >1400 seaweed flies identified known and candidate genomic inversions
 ([[Mérot and coll, 2021|biblio/33963409]]).
 
@@ -12,6 +14,12 @@ SV analysis of 31 diploid assemblies of _Theobroma cacao_ showed relaxed
 selection and increased genetic load in inversions and other types of variants
 [[Hämälä and coll., 2021|biblio/34408075]].
 
+~1100 small-scale inversions are estimated to have happened between _S.
+cerevisiae_ and _C. albicans_ ([[|biblio/11087826]]).  The authors propose that
+“successive multigene inversions” have “distrupted” the “precise arrangement”
+of “genes that are adjacent in one species are in the same neighborhood”.  A
+“bias toward small inversions” is reported.
+
 ### Software
 
  - _NanoSV_ ([[Cretu Stancu and coll., 2017|biblio/29109544]]) uses nanopore long