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+[[!meta title="Mixing genome annotation methods in a comparative analysis inflates the apparent number of lineage-specific genes."]]
+[[!tag annotation method]]
+
+Weisman CM, Murray AW, Eddy SR.
+
+Curr Biol. 2022 May 12:S0960-9822(22)00721-7. doi:10.1016/j.cub.2022.04.085
+
+Mixing genome annotation methods in a comparative analysis inflates the apparent number of lineage-specific genes.
+
+[[!pmid 35588743 desc="“In all but one of the eight cases in Figure 1, the increase is more than 2-fold, suggesting that the majority of lineage-specific genes inferred in heterogeneous annotations are artifacts of the heterogeneity.”  “As expected, six-frame translation homology searches dramatically reduce the apparent number of lineage-specific genes.”"]]