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+[[!meta title="Causes and Effects of Loss of Classical Nonhomologous End Joining Pathway in Parasitic Eukaryotes."]]
+[[!tag review repair Oikopleura]]
+
+Nenarokova A, Záhonová K, Krasilnikova M, Gahura O, McCulloch R, Zíková A, Yurchenko V, Lukeš J.
+
+mBio. 2019 Jul 16;10(4):e01541-19. doi:10.1128/mBio.01541-19
+
+Causes and Effects of Loss of Classical Nonhomologous End Joining Pathway in Parasitic Eukaryotes.
+
+[[!pmid 31311886 desc="Reviews possible advantages of losing the C-NHEJ pathway, such as reduction of transposon movement, reduction of genome size and change of genome structure, and insertion of short new sequence in proteins.  Focus on parasites but some facts about Oikopleura are highlighted for comparison purposes."]]

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@@ -270,6 +270,8 @@ Genes and pathways
    conserved from yeast to mammals) is undetectable ([[Denoeud et al., 2010|biblio/21097902]]).
    An alternative or microhomology (MH)-driven end joining pathway is active
    and triggers microdeletions at the joining site ([[Deng, Henriet and Chourrout, 2018|biblio/30293719]]).
+   Loss of C-NHEJ is often associated with parasitism, which is not the case in
+   _Oikopleura_ (review in [[Nenarokova and coll., 2019|biblio/31311886]]).
  - In line with the above, “There is no H2AX homolog in O. dioica.” (H2AX is
    implicated in DNA repair).  [[Moosmann and coll., 2011|biblio/21756361]]
  - The minor spliceosome could not be found in _Oikopleura_'s genome ([[Marz