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+[[!meta title="Ragout-a reference-assisted assembly tool for bacterial genomes."]]
+[[!tag genome assembly chromosome software method]]
+
+Bioinformatics. 2014 Jun 15;30(12):i302-9. doi:10.1093/bioinformatics/btu280
+
+Kolmogorov M, Raney B, Paten B, Pham S.
+
+Ragout-a reference-assisted assembly tool for bacterial genomes.
+
+[[!pmid 24931998 desc="Can accept multiple reference genomes. Decomposes refernces and target in synteny blocks and assemble them in a graph."]]
read length is satisfactory.
When coverage is too low for efficient reference-free assembly, related
-references can be used as a guide. The Ragout 2 software ([[Kolmogorov and
-coll., 2018|biblio/30341161]]) can take multiple reference genomes as input and
-automatically infers phylogenetic relationship between them. Polymorphisms
-unique to the target genome can be recovered, but chromosome fusions are
-typically hard to detect.
+references can be used as a guide. The Ragout software ([[Kolmogorov and
+coll., 2014|biblio/24931998), [[Kolmogorov and coll., 2018|biblio/30341161]])
+can take multiple reference genomes to guide the assembly of one target.
+Polymorphisms unique to the target genome can be recovered, but chromosome
+fusions are typically hard to detect. Compared to version 1, version 2 infers
+phylogenetic relationships between the reference genomes automatically.
The HaploMerger2 pipeline ([[Huang and coll., 2017|biblio/28407147]]) takes a
diploid assembly and outputs a reference and an alternative sub-assembly for