Café

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+[[!meta title="Chitin-based barrier immunity and its loss predated mucus-colonization by indigenous gut microbiota."]]
+[[!tag cellulose tunicate Ciona]]
+
+Nakashima K, Kimura S, Ogawa Y, Watanabe S, Soma S, Kaneko T, Yamada L, Sawada H, Tung CH, Lu TM, Yu JK, Villar-Briones A, Kikuchi S, Satoh N.
+
+Nat Commun. 2018 Aug 24;9(1):3402. doi:10.1038/s41467-018-05884-0
+
+Chitin-based barrier immunity and its loss predated mucus-colonization by indigenous gut microbiota.
+
+[[!pmid 30143642 desc="The gut cells of _Ciona robusta_ are protected by a membrane made of cellulose and chitin, that bacteria can not cross.  The three most abundant proteins in this membrane are Ci-MACPF1, related to perforins, variable region-containing chitin-binding protein (VCBP), and Ci-GFM1, a gel-forming mucin.  Thus, the tunicate gut has features related to insects (chitin barrier) and vertebrates (mucin barrier)."]]

diff --git a/tags/Ciona.mdwn b/tags/Ciona.mdwn
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+++ b/tags/Ciona.mdwn
@@ -102,4 +102,8 @@ with respcet to _C. roulei_ ([[Nydam and Harrison, 2010|biblio/20403444]]).
 Blood cells of _C intestinalis_ (_robusta_?) contain vanadium ([[Michibata,
 1996|biblio/10.2108_zsj.13.489]]).
 
+The gut barrier of _Ciona robusta_ is made of chitin, cellulose, perforins,
+chitin-binding proteins and mucins ([[Nakashima and coll.,
+2018|biblio/30143642]]).
+
 [[!inline pages="tagged(Ciona)" actions="no" limit=0]]