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+[[!meta title="Muscle5: High-accuracy alignment ensembles enable unbiased assessments of sequence homology and phylogeny."]]
+[[!tag alignment software]]
+
+Nat Commun. 2022 Nov 15;13(1):6968. doi:10.1038/s41467-022-34630-w
+
+Edgar RC.
+
+Muscle5: High-accuracy alignment ensembles enable unbiased assessments of sequence homology and phylogeny.
+
+[[!pmid 36379955 desc="Random variations of HMM parameters and guide trees in different replicates to explore systematic biases and remove them by averaging the replicates.  “Unlike typical conservation-based metrics, a column with many gaps or with biochemically dissimilar amino acids will be assigned high [confidence] if it is consistently reproduced.”"]]