RA

diff --git a/biblio/27406791.mdwn b/biblio/27406791.mdwn
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+[[!meta title="Coelimination and Survival in Gene Network Evolution: Dismantling the RA-Signaling in a Chordate."]]
+[[!tag Oikopleura]]
+
+Martí-Solans J, Belyaeva OV, Torres-Aguila NP, Kedishvili NY, Albalat R, Cañestro C. 
+
+Mol Biol Evol. 2016 Sep;33(9):2401-16. doi:10.1093/molbev/msw118 
+
+Coelimination and Survival in Gene Network Evolution: Dismantling the RA-Signaling in a Chordate. 
+
+[[!pmid 27406791 desc="Some genes are lost (_Aldh1a_, _Cyp26_, _Rdh10_, _Rdh16_, and _Bco1_) and others show signs of neofunctionalisation (_RdhE2_, _Aldh8a1_). “_O. dioica_ did not contain atRA at concentrations that were likely to play any role in developmental or physiological processes.”"]]

diff --git a/tags/Oikopleura.mdwn b/tags/Oikopleura.mdwn
index b9deb0589751f8b99b449b0c96a044f4efcb90f5..affc1fba768084e8f52a73b67216980955fc16e7 100644 (file)
--- a/tags/Oikopleura.mdwn
+++ b/tags/Oikopleura.mdwn
@@ -136,6 +136,11 @@ Physiology
  - Adh3 is the only medium-chain alcohol dehydrogenase (MDR-Adh) in _Oikopleura_
    (like in other non-vertebrates).  Conservation of critical residues and similarity
    in expression pattern suggest that its metabolic targets are the same as in other species.
+ - Most members of retinoic acid pathway gene network (biosynthesis, signalling
+   and degradation) are lost in _O. dioica_.  Some of the remaining ones show
+   signs of neofunctionalisation or specialisation in their ancestral activity in
+   digestion or chemical defence. ([Martí-Solans et al., 2016|biblio/27406791]) 
+
 
 Phenotypes
 ----------