Ce matin.

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+[[!meta title="The human noncoding genome defined by genetic diversity."]]
+[[!tag non_coding variability]]
+
+Nat Genet. 2018 Mar;50(3):333-337. doi:10.1038/s41588-018-0062-7
+
+di Iulio J, Bartha I, Wong EHM, Yu HC, Lavrenko V, Yang D, Jung I, Hicks MA, Shah N, Kirkness EF, Fabani MM, Biggs WH, Ren B, Venter JC, Telenti A.
+
+The human noncoding genome defined by genetic diversity.
+
+[[!pmid 29483654 desc="Study of the variation of on the 4th base of all possible heptamers in the human genome.  Defined “context-dependent tolerance score (CDTS)” as “the absolute difference of the observed variation from the expected variation” in genomic windows, using  7,794 unrelated genomes.  Identifies non-conserved, non-protein regions with human-specific sequence constraints."]]