au bureau.

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+[[!meta title="CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity."]]
+[[!tag CRISPR HPV method]]
+
+Science. 2018 Feb 15. pii: eaar6245. doi:10.1126/science.aar6245
+
+Chen JS, Ma E, Harrington LB, Da Costa M, Tian X, Palefsky JM, Doudna JA.
+
+CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity.
+
+[[!pmid 29449511 desc="DNA Endonuclease Targeted CRISPR Trans Reporter (DETECTR).  Cas12a activates a single-strand nuclease after matching its target double-strand DNA.  A single-strand probe terminated by a fluorophore and a quencher signals the activation."]]