Le mieux est l'ennemi du bien.

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+[[!meta title="A paradoxical teratogenic mechanism for retinoic acid."]]
+[[!tag dosage regulation]]
+
+Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13668-73.
+
+Lee LM, Leung CY, Tang WW, Choi HL, Leung YC, McCaffery PJ, Wang CC, Woolf AS, Shum AS.
+
+A paradoxical teratogenic mechanism for retinoic acid.
+
+[[!pmid 22869719 desc="High-level exposure durably downregulates pathway and causes deficiency later."]]