Science is in the air...

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+[[!meta title="Comparative genomics reveals conserved positioning of essential genomic clusters in highly rearranged Thermococcales chromosomes"]]
+[[!tag bacteria variants]]
+
+Matteo Cossu, Violette Da Cunha, Claire Toffano-Nioche, Patrick Forterre, Jacques Oberto
+
+Biochimie. 2015 Nov;118:313-21. doi:10.1016/j.biochi.2015.07.008
+
+Comparative genomics reveals conserved positioning of essential genomic clusters in highly rearranged Thermococcales chromosomes
+
+[[!pmid 26166067 desc="“The comparative genomics analysis presented here
+confirms the initial observation that Thermococcales chromosomes are highly
+rearranged. In these genomes, DNA sequence scrambling has reached such a high
+level that commonly observed prokaryotic chromosomal landmarks such as oriC and
+terC are no longer readily identifiable by measuring DNA composition
+biases.”"]]

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@@ -67,7 +67,9 @@ The state of the art in bacterial genomics in 2000 was reviewed by
 
 A mixture of X-shaped dot-plot pattern and scrambling was reported by
 [[Zivanovic and coll. (2002)|biblio/11972326]] in a study of _Pyrococcus_
-genomes.
+genomes.  Scrambling in _Thermococcales_ appears to be fast enough that
+the usual compositional biases on both sides of the origin of replication
+do not have time to establish ([[Cossu and coll., 2015|biblio/26166067]]).
 
 ### Mechanism