Some time ago.

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+[[!meta title="scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells."]]
+[[!tag transcriptome single_cell epigenetic methylation]]
+
+Nat Commun. 2018 Feb 22;9(1):781. doi:10.1038/s41467-018-03149-4
+
+Clark SJ, Argelaguet R, Kapourani CA, Stubbs TM, Lee HJ, Alda-Catalinas C, Krueger F, Sanguinetti G, Kelsey G, Marioni JC, Stegle O, Reik W.
+
+scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells.
+
+[[!pmid 29472610 desc="GpC methyltransferase need accessibiltiy to the native chromatin.  RNA and DNA are split primor amplification.  SMART-seq on RNA and bisulfite (scBS) on DNA. Throughput limited by the DNA/RNA separation."]]