H4K20me2

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+[[!meta title="Histone H4 post-translational modifications in chordate mitotic and endoreduplicative cell cycles."]]
+[[!tag Oikopleura H4K20me2 H3S28p H3S10p H4K16Ac]]
+
+Spada F, Chioda M, Thompson EM.
+
+J Cell Biochem. 2005 Aug 1;95(5):885-901. doi:10.1002/jcb.20416
+
+Histone H4 post-translational modifications in chordate mitotic and endoreduplicative cell cycles.
+
+[[!pmid 15937898 desc="Knobs are also seem to be in H4K20me2.  In endocycling cells, H4K20me2 tends to be stronger in BrdU-negative (short pulse) cells.  CldU/IdU staining confirms that H4K20me2 decreases during the S phase of endocycling cells.  In mitotically cycling cells, BrdU-low cells tended to be H4K20me2-weak.  Strong H3S28p and H3S10p staining (M phase markers) correlated with strong H4K20me2 staining.  In NIH3T3 cells, H4K20me2 peaks at M phase and then decreases from G1 to G2.  H4K16Ac stainings were not reproducible across antibodies."]]

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 ---------`
 
  - “Knobs” of heterochromatin strongly marked by H3K9me3 and enriched in H3K4me3 are prominent in
-   endocycling cells ([[Spada, Vincent and Thompson (2005)|biblio/15791412]]).
+   endocycling cells ([[Spada, Vincent and Thompson (2005)|biblio/15791412]]).  H4K20me2 also
+   seems to be enriched ([[Spada, Chioda and Thompson (2006)|biblio/15937898]]).
  - Histone 3.3 phosphorylation is seen in mitotic and meiotic cells, but not in
    endocycling ones ([[Schulmeister, Schmid and Thompson, 2007|biblio/17333540]]).
  - Some 5-methylcytosine was detected by MeDIP-chip by ([[Navratilova et al., 2017|biblio/28115992]]).
  - Chromatin domains are rarely longer than 7 nucleosomes ([[Navratilova et al., 2017|biblio/28115992]]).
-
+ - H4K20me2 decreases during S phase.  In mitotic cells, it then increases at M
+   phase, while in endocycling cells, it increases directly after the end of
+   the S phase ([[Spada, Chioda and Thompson (2006)|biblio/15937898]]).
 
 Transcriptome
 -------------