Café

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+[[!meta title="Production of retinoic acid by engineered Saccharomyces cerevisiae using an endogenous aldehyde dehydrogenase."]]
+[[!tag synthetic yeast]]
+
+Hu Q, Yu H, Ye L.
+
+Biotechnol Bioeng. 2022 Jul 26. doi:10.1002/bit.28192
+
+Production of retinoic acid by engineered Saccharomyces cerevisiae using an endogenous aldehyde dehydrogenase.
+
+[[!pmid 35880393 desc="Screen for the most efficient aldehyde dehydrogenases to produce retinoic acid in S. cerevisiae strain Y03 identified MmAldh, which was used to scan the yeast genome for an endogenous replacement.  Hfd1 was found, and increasing its copy number lead to the best yields."]]

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 _in progress_
 
+## Genomes
+
 Sc3.0 roadmap: [[Dai and coll., 2020|biblio/32791980]].
 
 “Biosynthesis of medicinal tropane alkaloids in yeast”: [[Srinivasan and Smolke and coll., 2020|biblio/32879484]]
@@ -10,4 +12,8 @@ Example of neochromosome synthesis in yeast: [[Postma and coll., 2021|biblio/334
 
 Artificial genome scrambling in yeast 2.0 with loxPsym sites: [[Brooks and coll, 2022|biblio/35239377]].
 
+## Pathway
+
+Increasing the copy number of the endogenous aldehyde dehydrogenase Hfd1 allowed [[Hu, Yu and Ye, 2022|biblio/35880393]] to obtain the best yield of conversion of retinol to retinoic acid..
+
 [[!inline pages="tagged(synthethic)" limit=0]]