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+[[!meta title="Emergence of novel cephalopod gene regulation and expression through large-scale genome reorganization."]]
+[[!tag genome synteny]]
+
+Emergence of novel cephalopod gene regulation and expression through large-scale genome reorganization.
+
+Nat Commun. 2022 Apr 21;13(1):2172. doi:10.1038/s41467-022-29694-7
+
+Schmidbaur H, Kawaguchi A, Clarence T, Fu X, Hoang OP, Zimmermann B, Ritschard EA, Weissenbacher A, Foster JS, Nyholm SV, Bates PA, Albertin CB, Tanaka E, Simakov O.
+
+[[!pmid 35449136 desc="Defines “microsyntenic blocks as at least three or more co-occurring orthologous genes with up to five intervening genes with no constraints on their collinearity”. Found 505 microsyntenies unique to cephalopods and 275 unique to metazooans.  “Genes in cephalopod-specific microsyntenies do not tend to be co-expressed, despite their tight co-localization”  “In contrast [to cephalopod-specific microsyntenies], conserved metazoan microsyntenies show significant (Wilcoxon test, p ≤ 0.001) co-expression when compared to simulated microsyntenies”"]]