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+[[!meta title="Contrasting modes of macro and microsynteny evolution in a eukaryotic subphylum."]]
+[[!tag yeast synteny]]
+
+Li Y, Liu H, Steenwyk JL, LaBella AL, Harrison MC, Groenewald M, Zhou X, Shen XX, Zhao T, Hittinger CT, Rokas A.
+
+Curr Biol. 2022 Dec 19;32(24):5335-5343.e4. doi:10.1016/j.cub.2022.10.025
+
+Contrasting modes of macro and microsynteny evolution in a eukaryotic subphylum.
+
+[[!pmid 36334587 desc="“conservation index is calculated by counting the number of one-to-one orthologous gene pairs whose genes are in homologous chromosomes/scaffolds and dividing it by the number of one-to-one orthologs whose genes reside in non-homologous chromosomes/scaffolds” “we found a faster decay of macrosynteny conservation compared with filamentous fungi and animals, which is corroborated by findings of rapid chromosome structure evolution in budding yeasts” “at the small-scale gene-level of organization, we identified both deeply conserved and lineage-specific instances of conservation of microsynteny across budding yeast genomes.”"]]
Squid chromosomes still have synteny with scallop, but gene order is scrambled
([[Albertin and coll., 2022|biblio/35508532]]).
+At equal evolutionary distance, yeast microsynteny is lower than in animals,
+but higher than in plants ([[Li and coll., 2022|biblio/36334587]]).
+
### Ancestral karyotpyes
- The ancestral mammalian genome has 30 chromosomes ([[Zhou and coll., 2021|biblio/33408411]]).