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+[[!meta title="Integration of CpG-free DNA induces de novo methylation of CpG islands in pluripotent stem cells."]]
+[[!tag CpG epigenetic promoter]]
+
+Science. 2017 May 5;356(6337):503-508. doi:10.1126/science.aag3260
+
+Takahashi Y, Wu J, Suzuki K, Martinez-Redondo P, Li M, Liao HK, Wu MZ, Hernández-Benítez R, Hishida T, Shokhirev MN, Esteban CR, Sancho-Martinez I, Belmonte JCI.
+
+Integration of CpG-free DNA induces de novo methylation of CpG islands in pluripotent stem cells.
+
+[[!pmid 28473583 desc="“both interruption of the methylation-blocking machinery and re- pression of transcriptional activity are necessary and sufficient to trigger de novo CGI methylation in PSCs”"]]