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+[[!meta title="Principles of genome evolution in the Drosophila melanogaster species group."]]
+[[!tag variants Drosophila]]
+
+Ranz JM, Maurin D, Chan YS, von Grotthuss M, Hillier LW, Roote J, Ashburner M, Bergman CM.
+
+PLoS Biol. 2007 Jun;5(6):e152. doi:10.1371/journal.pbio.0050152
+
+Principles of genome evolution in the Drosophila melanogaster species group.
+
+[[!pmid 17550304 desc="“the breakpoint regions of 59% of the inversions (17/29) are associated with inverted duplications of genes or other nonrepetitive sequences”  “We propose that the presence of inverted duplications associated with inversion breakpoint regions is the result of staggered breaks, either isochromatid or chromatid, and that this, rather than ectopic exchange between inverted repetitive sequences, is the prevalent mechanism for the generation of inversions in the melanogaster species group”  “The overall rate of breakage in the _D. melanogaster_ / _D. yakuba_ lineage is 0.0183/Mb/Myr.”"]]

diff --git a/tags/variants.mdwn b/tags/variants.mdwn
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--- a/tags/variants.mdwn
+++ b/tags/variants.mdwn
@@ -28,6 +28,14 @@ In the _Drosophila pseudoobscura / persimilis_ species complex, chromosomal inve
 suppress crossovers not only inside the inversion but also close to it (within 1–2 Mb)”
 ([[Machado, Haselkorn and Noor (2007)|biblio/17179068])].
 
+The overall rate of breakage in the _D. melanogaster_ / _D. yakuba_ lineage
+calculated by ([[Ranz and coll., 2007|bilbio/17550304]]) is 0.0183/Mb/Myr.  The
+authors “propose that the presence of inverted duplications associated with
+inversion breakpoint regions is the result of staggered breaks, either
+isochromatid or chromatid, and that this, rather than ectopic exchange between
+inverted repetitive sequences, is the prevalent mechanism for the generation of
+inversions in the melanogaster species group”. 
+
 [[Stefansson and coll, 2005||biblio/15654335]] found an inversion in the human
 genome and calculated that it appeared ~3 million years ago, before the
 speciation of _Homo sapiens_.  Low-copy repeated sequences were found in the