[[!meta title="Reverse transcriptases can clamp together nucleic acids strands with two complementary bases at their 3'-termini for initiating DNA synthesis."]]
[[!tag template_switching enzyme manganese]]
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+Oz-Gleenberg I, Herschhorn A, Hizi A.
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+Nucleic Acids Res. 2011 Feb;39(3):1042-53. doi: 10.1093/nar/gkq786
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+Reverse transcriptases can clamp together nucleic acids strands with two complementary bases at their 3'-termini for initiating DNA synthesis.
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[[!pmid 20876692 desc="AT-rich cDNA tails are not triggering template-switching well. CC are the strongest. Mn₂⁺ potentiates template switching for MMLV. dGTP stabilises the clamp between the enzyme and the nucleic acids."]]