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+[[!meta title="Large-scale genomic rearrangements boost SCRaMbLE in Saccharomyces cerevisiae."]]
+[[!tag yeast synthetic]]
+
+Cheng L, Zhao S, Li T, Hou S, Luo Z, Xu J, Yu W, Jiang S, Monti M, Schindler D, Zhang W, Hou C, Ma Y, Cai Y, Boeke JD, Dai J.
+
+Nat Commun. 2024 Jan 26;15(1):770. doi:10.1038/s41467-023-44511-5
+
+Large-scale genomic rearrangements boost SCRaMbLE in Saccharomyces cerevisiae.
+
+[[!pmid 38278805 desc="“SparLox83R, a yeast strain containing 83 loxPsym sites distributed across all 16 chromosomes” “LOH and aneuploidy are frequently detected in SCRaMbLEd heterozygous diploids” “the proportion of rearrangement events was 10-fold higher in haploid than in diploid cells.”"]]
Artificial 18 kbp random chromosome in yeast: [[Gvozdenov, Barcutean and Struhl, 2023|biblio/37137302]].
+SparLox83R contains 83 loxPsym sites distributed across all 16 chromosomes ([[Cheng and coll., 2024|biblio/38278805]]).
+
## Pathway
Increasing the copy number of the endogenous aldehyde dehydrogenase Hfd1