Café

diff --git a/biblio/31958060.mdwn b/biblio/31958060.mdwn
new file mode 100644 (file)
index 0000000..75b2014
--- /dev/null
+++ b/biblio/31958060.mdwn
@@ -0,0 +1,10 @@
+[[!meta title="Loss of centromere function drives karyotype evolution in closely related Malassezia species."]]
+[[!tag chromosome centromere yeast]]
+
+Sankaranarayanan SR, Ianiri G, Coelho MA, Reza MH, Thimmappa BC, Ganguly P, Vadnala RN, Sun S, Siddharthan R, Tellgren-Roth C, Dawson TL Jnr, Heitman J, Sanyal K.
+
+Elife. 2020 Jan 20;9. pii: e53944. doi: 10.7554/eLife.53944 doi:10.7554/eLife.53944
+
+Loss of centromere function drives karyotype evolution in closely related Malassezia species.
+
+[[!pmid 31958060 desc="Hypothetises that AT-richness at centromeres can trigger breaks, and structural changes.  Centromeres detected by ChIP-seq on GFP-Mtw1 in M. sympodialis.  ”PhyloGibbs-MP predicted a 12 bp long AT-rich 239 motif common to all of the centromere sequences.”  “In each chromosome, the centromere region shows between 7 and 13 motif matches, while no other 500 bp window shows more than 3 matches.”  “In the absence of any centromere exclusive DNA sequence, the unique and distinguishing features of centromere regions in M. sympodialis are an AT-rich core region of <1 kb [...] enriched with the 12 bp motif in a kinetochore protein-bound region of 3 to 5 kb [containing] a reduced level of histone H3.”  “Syntenic regions of all 8 M. sympodialis centromeres are present in the genomes of M. globosa and M. slooffiae [(each carries 9 chromosomes)].”  “In the case of M. restricta, 7 putative centromeres are completely syntenic with M. sympodialis centromeres and one centromere retained partial gene synteny.”  “No gene synteny conservation was observed at the centromeres of Chr2 in M. globosa, Chr5 in M. slooffiae, or Chr8 in M. restricta, indicative of loss of a centromere during the transition from the 9-chromosome state to the 8-302 chromosome state.”"]]

diff --git a/tags/centromere.mdwn b/tags/centromere.mdwn
index f3ba342060aff4bc53377159485abbd7a62039f9..8b7d5d3595390f8e424e22bb600dc89003eaa86e 100644 (file)
--- a/tags/centromere.mdwn
+++ b/tags/centromere.mdwn
@@ -1,4 +1,14 @@
 [[!meta title="pages tagged centromere"]]
 
-[[!inline pages="tagged(centromere)" actions="no" archive="yes"
-feedshow=10]]
+_Work in progress_
+
+ - Brute-force analysis to find the most abundant large tandem repeat can find
+   centromeres ([[Melters and coll., 2013|biblio/23363705]]).
+ - In medaka, study of homologous pairs of centromeres suggest that the
+   acrocentric ones evolve slower ([[Ichikawa and coll., 2017|biblio/29184138]]).
+ - In Oikopleura (and many others) H3S28p marks mitotic centromeres [[Fent and
+   coll., 2019|biblio/31306061]].
+ - Centromere breakage and inactivation in yeast: [[Sankaranarayanan and coll.,
+   2020|biblio/31958060]].
+
+[[!inline pages="tagged(centromere)" limit="0"]]