privés de dessert

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+[[!meta title="Lifespan extension in a semelparous chordate occurs via developmental growth arrest just prior to meiotic entry."]]
+[[!tag Oikopleura H3S28p]]
+
+PLoS One. 2014 Apr 2;9(4):e93787. doi:10.1371/journal.pone.0093787
+
+Subramaniam G, Campsteijn C, Thompson EM.
+
+Lifespan extension in a semelparous chordate occurs via developmental growth arrest just prior to meiotic entry.
+
+[[!pmid 24695788 desc="Growth arrest (GA) discovered by culturing animals in crowded conditions, but can also be striggered by reduction of food intake before D4.  After that, starvation reduces the number of gametes produced instead of inducing GA.  In GA, cell cycle stops in both the somatic and germ lines.  GA can also be induced by the TOR inhibitor CCI-779.  Animals in GA can survice up to ~18 days at 15°C."]]

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@@ -260,6 +260,10 @@ Development
    culture conditions might differ.
  - Increased food abundance increases egg number but does not change diameter nor
    generation time ([[Troedsson and coll., 2002|biblio/10.3354_meps243083]]).
+   Food reduction before day 4 causes growth arrest (GA), in which all cell cycles
+   eventually pause.  Animals in GA can survive ~18 days at 15°C.  GA can also be
+   induced by inhibiting the TOR pathway ([[Subramaniam, Campsteijn and Thompson,
+   2014|biblio/24695788]]).
  - Colchicine treatment induced early differenciation of the oocytes
    ([[Ganot, Kallesøe, Thompson (2007)|biblio/17123503]]).
  - Telomeres are localised at the nuclear envelope and do not overlap with nuclear