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diff --git a/biblio/30272001.mdwn b/biblio/30272001.mdwn
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@@ -0,0 +1,10 @@
+[[!meta title="Diatom bloom-derived biotoxins cause aberrant development and gene expression in the appendicularian chordate Oikopleura dioica"]]
+[[!tag Oikopleura]]
+
+Commun Biol. 2018 Aug 24;1:121. doi:10.1038/s42003-018-0127-2
+
+Torres-Águila NP, Martí-Solans J, Ferrández-Roldán A, Almazán A, Roncalli V, D'Aniello S, Romano G, Palumbo A, Albalat R, Cañestro C.
+
+Diatom bloom-derived biotoxins cause aberrant development and gene expression in the appendicularian chordate Oikopleura dioica
+
+[[!pmid 30272001 desc="Polyunsaturated aldehydes released by diatoms impair the development of O. dioica by delaying the onset of expression of developmental genes.  Cell proliferation is not affected and “defensome” genes such as Aldh genes or Gclm (Glutamate-cysteine ligase modifier) are induced by the toxins.  Chaetoceros calcitrans, a diatom used as food when culturing O. dioica, is also shown to have a toxic effect."]]

diff --git a/tags/Oikopleura.mdwn b/tags/Oikopleura.mdwn
index 5467f6efce8ca876cc34217eeadb59b52aaa7d48..f074d6f2162d239968e01c70e0392ccd2403040b 100644 (file)
--- a/tags/Oikopleura.mdwn
+++ b/tags/Oikopleura.mdwn
@@ -25,6 +25,9 @@ Some links:
 Food tested in laboratory (totally incomplete list): _Isochrysis galbana_ (5.5
 µm in size), _Tetraselmis suecica_ (9.5 µm), and the chlorophyte _Chlorella
 sp._ (3.5 µm) [[Acuña and Kiefer, 2000|biblio/10.4319_lo.2000.45.3.0608]].
+The diatom Chaetoceros calcitrans, often used as a food, can be toxic at high
+concentrations, probably because of the production of biotoxins
+([[Torres-Águila and coll., 2018|biblio/30272001]]).
 
 Parasites: _Oodinium pouchetii_ and others.
 
@@ -124,6 +127,9 @@ Genes and pathways
    tail movements at larval and adult stages.
  - No olfactory receptors have been found in _Oikopleura_ nor in _Ciona_
    ([[Niimura, 2009|biblio/20333175]]).
+ - Defensome genes such as dehydrogenases and  (Glutamate-cysteine ligase modifier subunit; Gclm)
+   are activated by polyunsaturated aldehydes produced by diatoms
+   ([[Torres-Águila and coll., 2018|biblio/30272001]]).
 
 Transcriptome
 -------------
@@ -193,7 +199,8 @@ Development
    experiments indicate that the posterior portion of the tail is required for
    posterior migration of subchordal cell precursors ([[Kishi and coll,
    2014|biblio/25224225]]).
-
+ - Expression of development genes is retarded by polyunsaturated aldehydes produced
+   by diatoms ([[Torres-Águila and coll., 2018|biblio/30272001]]).
 
 Anatomy
 -------