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+[[!meta title="Biosynthesis of medicinal tropane alkaloids in yeast."]]
+[[!tag yeast synthetic]]
+
+Srinivasan P, Smolke CD.
+
+Nature. 2020 Sep;585(7826):614-619. doi:10.1038/s41586-020-2650-9
+
+Biosynthesis of medicinal tropane alkaloids in yeast.
+
+[[!pmid 32879484 desc="“Our final strain comprises 34 chromosomal modifications (26 genes, 8 gene disruptions), resulting in an integrated whole-cell system that expresses enzymes and transporters in diverse sub-cellular locations (cytosol, mitochondria, peroxisome, vacuole, ER and vacuolar membranes)”  Screened a plant RNA-seq to discover one of the enzymes.  Protein sequence needed modifications for proper trans-compartment transport and maturation in the yeast cells."]]