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+[[!meta title="Deeply conserved synteny and the evolution of metazoan chromosomes."]]
+[[!tag synteny]]
+
+Simakov O, Bredeson J, Berkoff K, Marletaz F, Mitros T, Schultz DT, O'Connell BL, Dear P, Martinez DE, Steele RE, Green RE, David CN, Rokhsar DS.
+
+Sci Adv. 2022 Feb 4;8(5):eabi5884. doi:10.1126/sciadv.abi5884
+
+Deeply conserved synteny and the evolution of metazoan chromosomes.
+
+[[!pmid 35108053 desc="29 ancestral linkage groups (ALG) or 24 bilaterian linkage groups, containg usually less than 100 genes.  Karyotypes change by insertion, fusion or "fusion with mixing" between chromosomes.  Traces of conserved synteny with unicellular genomes (choanoflagellates, ichtyosporeans) were found.]]

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@@ -65,6 +65,9 @@ phenomenon “mesosynteny”.
 
  - The ancestral amniote has 49 chromosomes ([[Sacerdot and coll., 2018|biblio/30333059]]).
 
+ - The ancestral bilaterian had 24 linkage groups according to [[Simakov and
+   coll., 2022|biblio/35108053]].
+
 ### Computational aspects
 
  - [[Rocha (2003)|biblio/14585609]] defines a Gene Order Conservation (GOC)