Café

diff --git a/biblio/33963409.mdwn b/biblio/33963409.mdwn
new file mode 100644 (file)
index 0000000..219e421
--- /dev/null
+++ b/biblio/33963409.mdwn
@@ -0,0 +1,12 @@
+[[!meta title="Locally adaptive inversions modulate genetic variation at different geographic scales in a seaweed fly"]]
+[[!tag variants genome]]
+
+Mérot C, Berdan E, Cayuela H, Djambazian H, Ferchaud AL, Laporte M, Normandeau E, Ragoussis J, Wellenreuther M, Bernatchez L.
+
+Mol Biol Evol. 2021 May 7:msab143. doi:10.1093/molbev/msab143
+
+Locally adaptive inversions modulate genetic variation at different geographic scales in a seaweed fly.
+
+[[!pmid 33963409 desc="Chromosomal assembly of Coelopa frigida.  SNP analysis and PCA revealed known and candidate genomic inversions."]]
+
+“We sampled the seaweed fly _Coelopa frigida_ along a bioclimatic gradient stretching across 10° of latitude, a salinity gradient and a range of heterogeneous, patchy habitats. We generated a chromosome-level genome assembly to analyse 1,446 low-coverage whole genomes collected along those gradients.“  “Analyses of more than 1,400 whole genomes of _C. frigida_ flies revealed four large chromosomal inversions affecting a large fraction of the genome (36.1Mb, 15%), and three low recombining genomic regions.”  “Among the 124,701 candidate SNPs identified by the GWAS, more than 99.8% were located in Cf-Inv(1)”  “At a finer geographic scale, outlier SNPs associated with wrackbed abiotic characteristics (depth, temperature and salinity) were strongly enriched in the inverted region Cf-Inv(1) with an odds ratio of 5, including outliers with very strong support”

diff --git a/tags/variants.mdwn b/tags/variants.mdwn
index 864be2d8f241432c29728272a6bf39c3e1d65b65..6eb4f28cc76abe199e9bf6a90820080cd4cb98fd 100644 (file)
--- a/tags/variants.mdwn
+++ b/tags/variants.mdwn
@@ -5,6 +5,9 @@ _in progress_
 Long read sequencing data from 3,622 Icelanders identified a median of 22,636
 SVs per individual (insertios: 13,353; deletions: 9,474) [[Beyter and coll, 2021|biblio/33972781]].
 
+SNP analysis in >1400 seaweed flies identified known and candidate genomic inversions
+([[Mérot and coll, 2021|biblio/33963409]]).
+
 ### Software
 
  - _NanoSV_ ([[Cretu Stancu and coll., 2017|biblio/29109544]]) uses nanopore long