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+[[!meta title="Polymorphic Centromere Locations in the Pathogenic Yeast Candida parapsilosis"]]
+[[!tag yeast centromere]]
+
+Ola M, O'Brien CE, Coughlan AY, Ma Q, Donovan PD, Wolfe KH, Butler G.
+
+Genome Res. 2020 May;30(5):684-696. doi:10.1101/gr.257816.119.
+
+Polymorphic Centromere Locations in the Pathogenic Yeast Candida parapsilosis
+
+[[!pmid 32424070 desc="HA epitope introduced into centromeric histone H3 (Cse4) using CRISPR-Cas9 editing.  ChIP-seq then identified centromeres.  “The species C. parapsilosis is therefore polymorphic for centromere location on two chromosomes. The centromere relocations are associated with a transition from a structured (IR) format to a format with no obvious structure or sequence dependence, within a single species. On Chromosome 5, it is likely that the centromeres on both copies of this chromosome have moved to a new location. It is possible that C. parapsilosis 90-137 is heterozygous at CEN1, with Cse4 at the expected location on one copy of Chromosome 1 and at a new location on the other copy.”  “The C. parapsilosis neocentromeres are formed at regions that are transcribed, and transcription is known to facilitate centromere activity in S. cerevisiae”"]]

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    coll., 2019|biblio/31306061]].
  - Centromere breakage and inactivation in yeast: [[Sankaranarayanan and coll.,
    2020|biblio/31958060]].
+ - Centromere relocation to a transcribed region in yeast, detected by ChIP of
+   centromeric H3 [[Ola and coll., 2020|biblio/32424070]].
 
 [[!inline pages="tagged(centromere)" limit="0"]]