Cystein

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+[[!meta title="Peculiar patterns of amino acid substitution and conservation in the fast evolving tunicate Oikopleura dioica."]]
+[[!tag Oikopleura]]
+
+Berná L, D'Onofrio G, Alvarez-Valin F.
+
+Mol Phylogenet Evol. 2012 Feb;62(2):708-17. doi:10.1016/j.ympev.2011.11.013
+
+Peculiar patterns of amino acid substitution and conservation in the fast evolving tunicate Oikopleura dioica.
+
+[[!pmid 22120064 desc="Faster evolution for regulatory genes.  High and even mutation rates for every aminoacid suggest a relaxation of functional constraints.  This is particularly surpising for cystein, which is highly conserved in other fast-evolving species such as Ciona.  The frequency of C is reduced of 10% compared with Ciona."]]

diff --git a/tags/Oikopleura.mdwn b/tags/Oikopleura.mdwn
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--- a/tags/Oikopleura.mdwn
+++ b/tags/Oikopleura.mdwn
@@ -110,6 +110,9 @@ Genome
  - Transcriptome comparisons between Atlantic and Pacific strains showed
    nucleotide and amino acid sequence similarities of 91.0 and 94.8 %,
    respectively ([[Wang and coll., 2015|biblio/26032664]]).
+ - Regulatory genes evolve faster.  All aminoacids, including cystein, show reduced
+   conservation, suggesting relaxation of functional constraints.  Compared with
+   Ciona, 10% of the cysteins are lost ([[Berná and coll., 2012|biblio/22120064]]).
 
 
 Genes and pathways