Vu à Stockholm.

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+[[!meta title="Genome sequencing of normal cells reveals developmental lineages and mutational processes."]]
+[[!tag single_cell organoid]]
+
+Behjati S, Huch M, van Boxtel R, Karthaus W, Wedge DC, Tamuri AU, Martincorena I, Petljak M, Alexandrov LB, Gundem G, Tarpey PS, Roerink S, Blokker J, Maddison M, Mudie L, Robinson B, Nik-Zainal S, Campbell P, Goldman N, van de Wetering M, Cuppen E, Clevers H, Stratton MR.
+
+Nature. 2014 Jun 29. doi:10.1038/nature13448
+
+Genome sequencing of normal cells reveals developmental lineages and mutational processes
+
+[[!pmid 25043003 desc="Genome amplification by organoid culture.  Mutation rate is higher at earlier developmental stages."]]