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diff --git a/biblio/32513727.mdwn b/biblio/32513727.mdwn
new file mode 100644 (file)
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+[[!meta title="Elimination of rNMPs from mitochondrial DNA has no effect on its stability."]]
+[[!tag mitochondrion]]
+
+Elimination of rNMPs from mitochondrial DNA has no effect on its stability.
+
+Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14306-14313
+
+Wanrooij PH, Tran P, Thompson LJ, Carvalho G, Sharma S, Kreisel K, Navarrete C, Feldberg AL, Watt DL, Nilsson AK, Engqvist MKM, Clausen AR, Chabes A.
+
+[[!pmid 32513727 desc="In mouse, mitochondrial DNA strands have a few (usually ~10 or less) ribonucleotides misincorporated into them.  Their number correlate with the ration between rNTPs and dNTPs.  Reducing misincorporation did not have obvious benefits for the animals. "]]

diff --git a/tags/mitochondrion.mdwn b/tags/mitochondrion.mdwn
index 355dde863f796be80c2f3df12e33b2fe87deaabb..318a642cc815657295cb92360014008cb4f5fc2f 100644 (file)
--- a/tags/mitochondrion.mdwn
+++ b/tags/mitochondrion.mdwn
@@ -87,4 +87,7 @@ Mitochondria can be lost in eukaryotes, be them monocellular ([[Karnkowska and
 coll., 2019|biblio/31387118]]), or multicellular ([[Yahalomi and coll.,
 2020|biblio/32094163]]).
 
+Mitochondrial DNA has a few rNTP misincorporated, but they do not seem to be
+detrimental ([[Wanrooij and coll., 2020|biblio/32513727]]).
+
 [[!inline pages="tagged(mitochondrion)" limit=0]]