Café

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+[[!meta title="Nkx2-1 and FoxE regionalize glandular (mucus-producing) and thyroid-equivalent traits in the endostyle of the chordate Oikopleura dioica."]]
+[[!tag Oikopleura]]
+
+Onuma TA, Nakanishi R, Sasakura Y, Ogasawara M.
+
+Dev Biol. 2021 Jun 6:S0012-1606(21)00142-1. doi: 10.1016/j.ydbio.2021.05.021.
+
+Nkx2-1 and FoxE regionalize glandular (mucus-producing) and thyroid-equivalent traits in the endostyle of the chordate Oikopleura dioica.
+
+[[!pmid 34107272 desc="Found vWFL (von Willebrand factor-like, a single gene, whereas Ciona has two), and the thyroid-related peroxidases, TPO and Duox, and the thyroid-related TFs Nkx2-1 and FoxE.  Also reported a SCO spondin in the supplemental material.  “Nkx2-1 knockdown suppressed vWFL expression in 8 hpf larvae. In contrast, FoxE knockdown had no effect on vWFL expression.”  “Nkx2-1 knockdown decreased TPO expression in the endostyle of over 90% of larvae.”  “FoxE knockdown did not affect Duox expression.”  “Nkx2-1 knockdown caused malformation of the endostyle in 80% of the larvae. In contrast, FoxE knockdown did not affect endostyle morphology.”  “Nkx2-1 expression was decreased by Nkx2-1 knockdown, but not by FoxE knockdown. On the other hand, FoxE expression was decreased in two-thirds of the Nkx2-1 knockdown larvae as well as in FoxE knockdown larvae.”"]]

diff --git a/tags/Oikopleura.mdwn b/tags/Oikopleura.mdwn
index c62f3acebbb7e0f932c83ae96419310d1fcf9fa0..86c71c2c914b04a9e4faf86d800af095ff8c28ab 100644 (file)
--- a/tags/Oikopleura.mdwn
+++ b/tags/Oikopleura.mdwn
@@ -236,6 +236,8 @@ Genes and pathways
  - Metallothioneins _OdMT1_ and _OdMT2_ [[Calatayud and coll., 2018|biblio/30284576]].
  - 2 NUMB genes were found; both are closer to Vertebrate NUMB than to Vertebrate NUMB-Like
    ([[Confalonieri and coll., 2019|biblio/31451549]]).
+ - Genes related to thyroid functions (_vWFL_, _Nkx2-1_, _FoxE_, _TPO_ and _Duox_)
+   were studied by [[Onuma and coll., 2020|biblio/34107272]].
 
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